Transient elastography (FibroScan®) in patients with chronic hepatitis C infection and haemophilia A

Introduction: In patients with bleeding disorders and chronic hepatitis C infection (CHC) liver biopsy for assessment of fibrosis stage is generally avoided because of potential hazardous complications, high costs and low patient acceptance. Thus, non-invasive methods for fibrosis staging are warranted. Methods: CHC patients with (CHC-A) and without haemophilia A (CHC-wo) were recruited and serum surrogate markers for fibrosis (APRI, Forns-Index) were determined. Transient elastography (FibroScan®) was performed in all patients and liver fibrosis stage in liver histology was recorded if available. Correlation of…