Can a constant bubble concentration be achieved during a long term infusion of Luminity™?

Aims: 1. To evaluate if a constant high concentration of contrast bubbles during long term infusion of 1.2mL ultrasound contrast agent (UCA) dissolved in 100mL saline over 15 and 33min can be achieved. 2. To evaluate if a constant low concentration of UCA dissolved in blood during a long term infusion over 16 and 33min can be achieved. Methods: 1.2mL Luminity™ dissolved in a bag of 100mL saline were infused through a silicon tube with a 3mm lumen running through a tissue mimicking phantom at a visually estimated volume flow rate of approximately 1 and 2 drops/second. Every 2 minutes a short cine loop was digital…