Healthy controls have the same hepatic transit time (HTT) using SonoVue® and Luminity® but using Levovist® the HTT is significantly longer

Objective: Liver metastases lead to a shortening of the HTT of an echo enhancer. Former studies using Optison® showed a HTT of about 16s in healthy controls. Optison is currently unavailable and recent observations indicated that SonoVue® has a shorter HTT than Optison®. Hence we compared the HTT of present available contrast agents in healthy controls. Method: 15 healthy controls with no visible liver lesions were enrolled in this study. We measured the HTT of three echo enhancers (SonoVue®, Luminity® and Levovist®), using low MI and CPS of Acuson sequoia®. The hepatic artery and a branch of the hepatic vein we…