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RASSF1A DNA methylation in bone marrow (mRASSF1ABM) or peripheral blood plasma (mRASSF1APB) of primary breast cancer (BC) patients

S Braun, D Auer, FD Vogl, A Schneitter, D Egle, S Taucher, G Daxenbichler, E Mueller-Holzner, C Marth · Senologie - Zeitschrift für Mammadiagnostik und -therapie · 2007 · Heft 09

Dokument
1106667
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Jahr
2007
Publikation
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Bibliografische Angaben

Zeitschrift
Senologie - Zeitschrift für Mammadiagnostik und -therapie
Autor:innen
S Braun, D Auer, FD Vogl, A Schneitter, D Egle, S Taucher, G Daxenbichler, E Mueller-Holzner, C Marth
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-24 00:00:00
ISSN
1611-6453
DOI
10.1055/s-2007-990357

Zusammenfassung

Purpose: mRASSF1APB (Fiegl et al. Cancer Res. 2005) has been described as an independent adverse prognostic factor in primary BC patients, reflecting presence of circulating tumor cells. In a series of 489 BC patients and 84 control patients, we assessed mRASSF1ABM (N=405) and mRASSF1APB (N=405). Methods: Positivity for mRASSF1A was defined as ≥1 ct values below 40.0 in a 50-cycles MethyLight-PCR (triplets per sample) after DNA bisulfite modification against a genomic RASSF1A standard. Results: We found mRASSF1ABM+ and mRASSF1APB+ in 79/405 (19.5%) and 73/405 (18.0%) BC patients, respectively. However, 14/84 (16…

Schlagworte

After Tumor Observation Breast Blood Senologie - Zeitschrift für Mammadiagnostik und -therapie