CareLit Fachartikel
Cox–2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells through generation of prostaglandin-gycerol est…
SV Siegmund, A Wojtalla, F Herweck, MV Singer · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
1106880
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Jahr
2008
Publikation
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Zusammenfassung
Aims: We have shown previously that the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG) is a lipid mediator that blocks proliferation and induces apoptosis in hepatic stellate cells (HSCs), but not in hepatocytes. However, the exact molecular mechanisms of this selective induction of HSC death still need to be clarified. AIM: To analyze a possible role of COX–2 in the differential cell death of primary HSCs and hepatocytes induced by 2-AG metabilization to pro-apoptotic prostaglandin D2 glycerol ester (PGD2-GE). Methods: Primary rat hepatocytes and rat HSCs were isolated from healthy rat liver by collagena…
Schlagworte
2-AG
COX-2
HSC
cell death
endocannabinoids
hepatocytes
Caspase 3
Reactive Oxygen Species
Apoptosis
Lead
After
Zeitschrift für Gastroenterologie
