IKK2 hepatocyte specific deletion accelerates the liver regeneration and enhances the innate immune response in mice
Y Malato, N Beraza, LE Sander, L Sander, M Al-Masaoudi, M Pasparakis, C Trautwein · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
After injury, the liver has the ability to restore its mass and function through a process called “liver regeneration“. In resting cells, NF-κB is confined inactive in the cytoplasm, bound to its inhibitor IκB. After stimulation, IκB is phosphorylated by the IKK complex (composed of two catalytic subunits IKK1 and IKK2 and a regulatory subunit NEMO) leading IκB to a proteasomal degradation and thus liberating NF-κB to translocate into the nucleus. As NF-κB is involved in early events of hepatocyte proliferation, we therefore studied the impact of hepatocyte-specific IKK2 deletion on liver regeneration. IKK2 cons…
