c-FLIP regulates hepatocyte apoptosis in vivo
M Schuchmann, J Schattenberg, J Siebler, H Schulze-Bergkamen, YW He, PR Galle · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocytes are highly susceptible to CD95 induced apoptosis and receptor mediated apoptosis is of particular importance in many liver diseases. CD95 (Fas) and CD120a (TNF-R1) are the most prominent cell death receptors in this context. Receptor aggregation upon ligand binding and subsequent recruitment of the adapter molecules FADD is a prerequisite for DISC formation, caspase–8 activation and subsequent initiation of the apoptotic machinery. The caspase–8 homologue FLIP exerts anti-apoptotic function and was shown to be involved in maturation and CD95 mediated apoptosis of T-cells (Zhang and He, JEM, 2005). He…
