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Reduced glomerular filtration rate is associated with poor sustained response rates to IFN/ribavirin in chronic hepatitis C

A Erhardt, C Desch, T Göbel, H Fey, U Heinzel-Pleines, D Häussinger · Zeitschrift für Gastroenterologie · 2008 · Heft 01

Dokument
1106894
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Erhardt, C Desch, T Göbel, H Fey, U Heinzel-Pleines, D Häussinger
Ausgabe
Heft 01 / 2008
Seiten
–
Erschienen: 2008-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2008-1037597

Zusammenfassung

Background an Aims: Ribavirin is mainly eliminated from serum through renal clearance. The present study investigated the influence of glomerular filtration rate on sustained virological response in HCV patients treated with ribavirin. Patients and Methods: A total of 341 consecutive patients treated with standard interferon and ribavirin (n=172) or pegylated interferon and ribavirin (n=169) were enrolled. GFR was calculated according to the Cockroft-Gault equation and categorised according to the KDOQI classification. Results: A reduced GFR below 90ml/min/1.73m2 was found in 36.1% of the patients, only 4.4% had…

Schlagworte

SVR chronic hepatitis C interferon therapy Anemia Hepatitis Zeitschrift für Gastroenterologie