Infection of primary human hepatocytes with recombinant hepatitis C virus
MB Zeisel, C Schuster, C Thumann, C Royer, E Soumier, P Bachellier, D Jaeck, M Doffoel, A Kaul, R Bartenschlager, TF Baumert · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of events required for initiation of infection. Results obtained with surrogate model systems for HCV infection using human hepatoma cell lines suggest that HCV entry is most likely a multi-step process which requires a set of initial binding molecules such as glycosaminoglycans, as well as (co)-receptors for viral entry such as CD81, SR-BI and claudin–1. However, it still remains elusive which host cell factors are required for HCV entry into its natural target cell, the human hepatocyte. In this study, we used th…
