Adiponectin downregulates connective tissue growth factor in hepatocytes and hepatic stellate cells
C Buechler, J Wanninger, M Neumeier, J Weigert, S Bauer, T Amann, TS Weiss, C Hellerbrand, A Schäffler, J Schoelmerich · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Objective: Connective tissue growth factor (CTGF) is synthesized by hepatocytes and hepatic stellate cells (HSC). CTGF enhances TGFbeta signalling and is a central player in liver fibrosis. Adiponectin protects from liver fibrosis, and here, we analysed whether these hepatoprotective effects may partly be driven by an impact of this adipokine on CTGF synthesis. Methods: Adiponectin mediated suppression of CTGF was identified by GeneChip analysis in hepatocytes and confirmed by real-time RT-PCR and immunoblot using primary human hepatocytes and hepatic stellate cells. Results: Suppression of CTGF by adiponectin i…
