CareLit Fachartikel
Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates inflammation and fibrosis in experimental NASH in vivo
K Dostert, R Wiest, J Schoelmerich, C Hellerbrand, E Gäbele · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1107106
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Non-alcoholic steatohepatitis (NASH) leads to liver fibrosis characterized by activation of hepatic stellate cells (HSC) and collagen expression. In vitro, we were able to show that PI3K, an ubiquitary, heterodimeric lipid kinase, participates in HSC proliferation and collagen expression (J Biol Chem 2005; 280(14): 13374–82). Further, PI3K is a key component of the insulin signalling pathway. Therefore, the aim of this study was to evaluate the role of PI3K in the development of experimental NASH. Methods and results: PI3K knockout mice (PI3K-/-, on a C57Bl/6 background) and C57Bl/6 wild-type control mice…
Schlagworte
Fibrosis
Inflammation
NASH
PI3K
Diet
Cholesterol
Cholate
Phosphatidylinositol 3-Kinase
Zeitschrift für Gastroenterologie
