Tumor specificity of viral replication has no impact on antitumoral immunity, but dictates antiviral immune response and toxicity of oncolytic therapy
E Gürlevik, N Woller, B Mundt, M Manns, L Zender, T Wirth, F Kühnel, S Kubicka · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
The immune response against cellular antigens due to viral infection is an important mechanism for autoimmune diseases, but can be also exploited for HCC immunotherapy. However, surprisingly little is known about the role of tissue specific viral replication on the induction of antiviral and anti-tissue immune responses. To investigate the impact of the specificity of viral replication on the immune responses we constructed a highly tumor-selective oncolytic adenovirus, whose replication is dependent on telomerase activity as well as aberrant transcriptional p53-status of the infected target cell. Viral DNA- and…
