Role of chemokine receptor and ATP-binding cassette transporter gene polymorphisms for biliary lesions following liver transplantation
S Iacob, V Cicinnati, A Dechêne, CG Klein, I Popescu, A Paul, G Gerken, S Beckebaum · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Ischemic type biliary lesions (ITBL) and anastomotic strictures (AS) are major complications following LT, leading to reduced graft and patient survival. Genetic polymorphisms in chemokine (CC) receptors which mediate leucocyte trafficking were reported to be associated with ITBL. For late AS, others than surgical factors should be incriminated. Genetic polymorphisms of ATP-binding cassette (ABC) transporters determine serum cholesterol level and cholesterol efflux into bile and contribute to production of lithogenic bile. Aim: To investigate the role of CC-receptors and ABC transporters for development of…
