CareLit Fachartikel
Epigenetic changes improve differentiation of hepatozyte-like cells from adipose tissue: possible application for cell therapies in surgery
C Seeliger, M Römer, M Culmes, S Ehnert, S Gillen, A Nuessler, U Stöckle · Zeitschrift für Gastroenterologie · 2010 · Heft 01
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1107115
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Jahr
2010
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Zusammenfassung
Question Due to donor organ scarcity, researchers nowadays focus on cell transplantation as alternative method to orthotopic liver transplantation. For this purpose, several groups attempt to generate hepatocyte-like cells from various adult stem or precursor cells such as mesenchymal stem cells (MSCs), fat tissue (Ad-) or liver. Aim of this study was to improve hepatic-function and amount of hepatocyte-like cells via epigenetic changes. Methods Human Ad-MSCs were isolated from different patients, with their informed consent according to ethical guidelines of the MRI. For hepatic differentiation several suppleme…
Schlagworte
Epigenetic changes
hepatozyte-like cells
transplantation
Dexamethasone
Work
After
Zeitschrift für Gastroenterologie
