CareLit Fachartikel
Determinants of CD8+ T cell exhaustion during chronic hepatitis C virus infection
B Bengsch, B Seigel, J Timm, H Pircher, HE Blum, R Thimme · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1107116
CareLit-ID
Jahr
2010
Publikation
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DOI
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Zusammenfassung
Recent studies have suggested that exhausted CD8+ T cell responses during chronic viral infections are defined by a complex coexpression pattern of inhibitory receptors next to PD-1. However, very little information is currently available about the expression patterns of these receptors on human virus-specific CD8+ T cells and their correlation with antiviral functions, T cell differentiation and antigen recognition. We addressed these important aspects in a cohort of 34 chronically HCV infected patients and found a co-expression of inhibitory receptors such as 2B4, CD160 and KLRG1 in association with PD-1 in ab…
Schlagworte
CD8+ T cell failure
HCV
hepatitis C virus
immunopathogenesis
viral escape
Association
Hepatitis
Zeitschrift für Gastroenterologie
