CareLit Fachartikel
Endothelial cell cross-presentation initiates TNFα-dependent CD8 T cell immunity against virus-infected hepatocytes
D Stabenow, K Gärtner, M Odenthal, M Krönke, U Protzer, HP Dienes, P Knolle · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1107120
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Viral infections in the liver are generally considered to be cleared in an MHC class I restricted killing of hepatocytes by CD8+ T cells. We believe that direct recognition of infected hepatocytes is an inefficient way and show that there exist an additional, more potent, mechanism. Using a tie2-H2-Kb transgenic mouse, where antigen is solely presented in the context of the MHC class I molecule H2-Kb on liver sinusoidal endothelial cells (LSEC) but not on hepatocytes, we detected liver damage after infection with AdOVA and adoptive transfer of OVA-specific CTLs. In contrast, presentation of antigen only on hepat…
Schlagworte
CD8
Hepatitis
LSEC
Apoptosis
After
Adoptive Transfer
Population
Cytokine
Lead
Zeitschrift für Gastroenterologie
