Simvastatin attenuates ventilator-induced lung injury in mice
HC Müller, M Witzenrath, K Hellwig, T Tschernig, A Schmiedel, B Gutbier, B Schmeck, S Hippenstiel, H Peters, N Suttorp, S Rosseau · Pneumologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Mechanical ventilation is a live saving intervention in acute respiratory failure without alternative. However, even protective ventilation strategies may evoke ventilator-induced lung injury (VILI), particularly in preinjured lungs. Thus, new adjuvant pharmacologic strategies are needed in addition to lung protective ventilation to attenuate ventilator induced lung injury. Simvastatin attenuated acute lung injury (ALI) by reduction of lung permeability and beneficial immunomodulation. Methods: Mice were ventilated (12ml/kg; 6h) and subjected to simvastatin (20mg/kg/d) or sham treatment. Pulmonary…
