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Calcium-binding proteins in rat and human pancreatic islets as well as in INS1-cells

I Bazwinsky-Wutschke, E Mühlbauer, L Litvak, E Peschke · Klinische Neurophysiologie · 2010 · Heft 03

Dokument
1107300
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Jahr
2010
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
I Bazwinsky-Wutschke, E Mühlbauer, L Litvak, E Peschke
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-02 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0030-1250857

Zusammenfassung

Introduction: Calcium is the central second messenger in the regulation of insulin release from the pancreatic β-cell. Transduction and efficacy of intracellular calcium signaling mainly depends on calcium-binding proteins (CaBPs) like calbindin-D28k (CALB), secretagogin (SCGN), calmodulin (CALM) and calreticulin (CALR). In pancreatic b-cells, the proposed functional role of these CaBPs includes the modulation of insulin secretion (CALB), influences on calcium influx and insulin transcription (SCGN), or modulation of insulin release via protein phosphorylation by calcium/calmodulin-dependent protein kinases (CAL…

Schlagworte

Calcium Calmodulin Calcium-Binding Proteins Calcium-Calmodulin-Dependent Protein Kinases Calcium Signaling Diabetes Mellitus Calreticulin Klinische Neurophysiologie