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Whole brain-based multiparametric MRI analysis of regional white matter tract alterations in rare motor neuron diseases by diffusion tensor imaging

A Unrath, HP Mueller, A Riecker, AD Sperfeld, AC Ludolph, J Kassubek · Klinische Neurophysiologie · 2010 · Heft 03

Dokument
1107304
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
A Unrath, HP Mueller, A Riecker, AD Sperfeld, AC Ludolph, J Kassubek
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-02 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0030-1250897

Zusammenfassung

Introduction: Different motor neuron disorders (MNDs) are mainly defined by the clinical presentation based on the predominance of upper or lower motor neuron impairment and the course of the disease. The present study was designed to investigate three different rare MNDs, i.e. primary lateral sclerosis (PLS), hereditary spastic paraparesis (HSP), and X-linked spinobulbar muscular atrophy (X-SBMA), by use of whole-brain based Diffusion Tensor Imaging (DTI) analysis in comparison with matched controls. Material and Methods: Fractional anisotropy (FA) mapping from DTI was applied to data sets of 25 PLS patients (8…

Schlagworte

Diffusion Tensor Imaging Diffusion Corpus Callosum Anisotropy Atrophy Klinische Neurophysiologie