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Examination of mitochondrial changes in patients with idiopathic inflammatory myopathies

P Tacik, P Joshi, M Deschauer, S Zierz, S Nikolin, J Weis · Klinische Neurophysiologie · 2010 · Heft 03

Dokument
1107316
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
P Tacik, P Joshi, M Deschauer, S Zierz, S Nikolin, J Weis
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-02 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0030-1251017

Zusammenfassung

Objectives: Mitochondrial changes were frequently reported in inclusion body myositis (IBM) and occasionally in dermatomyositis (DM) as well as in polymyositis (PM). The aim of this study was to analyse frequencies of myohistological mitochondrial changes and of a 4977 base pair deletion – so called common deletion (CD)-of mitochondrial DNA (mtDNA) in clinically well-described patients with IBM, DM and PM. Methods: Two examinations were carried out in 35 patients (10 IBM, 12 PM, 13 DM): (1) a quantitative analysis of myohistological mitochondrial changes using the cytochrome c oxidase/succinate dehydrogenase (CO…

Schlagworte

Creatine Kinase Dermatomyositis Cytochrome C Cytochrome Creatine Klinische Neurophysiologie