A neuronal NO synthase promoter polymorphism modifies ACC functioning in healthy controls and schizophrenia
A Reif, AC Ehlis, C Bähne, M Schecklmann, C Jacob, S Herterich, KP Lesch, A Fallgatter · Klinische Neurophysiologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Nitric oxide (NO), the second messenger of the NMDA receptor, is a gaseous neurotransmitter and interacts with both the dopaminergic and the serotonergic system. Genetic and pharmacological studies in animals have demonstrated a role for the neuronal isoform of nitric oxide synthase (nNOS, NOS-I) in a wide range of behaviors. We have previously indentified a repeat polymorphism in the promoter region of NOS1, termed NOS1 ex1f-VNTR, which controls gene expression and impacts on the neuronal transcriptome. By genotyping more than 5,000 individuals, we demonstrated that short variants of NOS1 ex1f-VNTR are associat…
