Structural Brain Abnormalities in Attention-Deficit/Hyperactivity Disorder: A Voxel-based MRI Study in Adult Patients

Objective: Most structural neuroimaging studies of subjects with attention-deficit/hyperactivity disorder (ADHD) have been conducted in children. The most replicated findings in ADHD children include significantly smaller volumes in the prefrontal cortex, basal ganglia, corpus callosum and cerebellum. In the present study, we investigated structural brain abnormalities in adult subjects with ADHD using voxel-based morphometry (VBM). Methods: 25 ADHD patients (14 males, mean age 32 years) and 25 age- and gender matched healthy control subjects (Table 1) underwent a detailed clinical interview as well as neuropsyc…