Spectrum of cognitive impairment including higher executive functions in patients with Multiple Sclerosis

Background: Cognitive dysfunction has been reported to occur in approximately 30 to 70% of patients with multiple sclerosis (MS). Rather than a global cognitive decline, typically Spectrum of cognitive impairment including higher executive functions in patients with Multiple Sclerosis rather subtle domain-specific deficits can be detected. Extrapolating the results from combined assessments of neuropsychology, structural and/or functional magnetic resonance imaging (MRI) supports the notion that cognitive impairment is not a simple function of tissue destruction, but rather modified by, mechanisms of tissue repa…