CareLit Fachartikel

Effect of pH and CO2 on hypoxic pulmonary vasoconstriction and capillary permeability – impact of NO

F Ketabchi, G Dehghani, R Schermuly, H Ghofrani, W Seeger, F Grimminger, N Weissmann · Pneumologie · 2008 · Heft 04

Dokument
1107685
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
F Ketabchi, G Dehghani, R Schermuly, H Ghofrani, W Seeger, F Grimminger, N Weissmann
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-07 00:00:00
ISSN
0934-8387
DOI
10.1055/s-2008-1074407

Zusammenfassung

Acute and chronic respiratory dysfunctions such as obstructive pulmonary diseases, chest wall neuromuscular disorders, and central nervous system depression, may induce alveolar hypoxia (HOX) and hypercapnia (HCP), which can affect systemic regulatory processes and pulmonary function. Although it is known that HOX induces a biphasic pulmonary vasoconstriction, there is still uncertainty about the effect of HCP in combination (HCPA) or without acidosis (HCPI) on the pulmonary vascular response. Therefore, we employed isolated perfused and ventilated rabbit lungs to determine the effects of HOX, HCPA and HCPI and…

Schlagworte

Ventilation Pulmonary Artery Compliance Depression Acidosis Affect Pneumologie