One-year way of carcinogenesis of a duodenal villous adenoma

Introduction: Villous adenoma of the descending duodenum of a seventy years old female was detected by endoscopy, endoscopic ultra-sonography, and histology. It was removed by surgical excision. The adenoma recurred one year later and its histological signs referred to malignant changes. The tumour was removed definitely by pylorus preserving pancreato-duodenectomy. The signs of supervening carcinogenesis were investigated immuno-histochemically. Method: The dysplastic changes were investigated on hematoxyllin-eosine (HE) staining, and the following immuno-histochemical markers: ki-67, p53, CEA, Ck AE1/AE3, EMA…