Association of β-defensin 1 single nucleotide polymorphisms with Crohn's disease
A Kocsis, F Somogyvari, P Fuszek, J Papp, S Fischer, T Szamosi, L Lakatos, A Kovacs, P Hofner, Y Mandi, P Lakatos · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: It has been suggested that deficient defensin expression is connected with the chronic inflammation of Crohn's disease. The regional localization of the Crohn's disease, ileal or colonic disease can be linked to different defensin profiles. As constitutive β-defensin 1 has a colonic expression, we considered it of interest to investigate single nucleotide polymorphisms (SNPs) of the β-defensin 1 gene (DEFB1) in Crohn's disease. Methods: Three SNPs of the DEFB1 gene DEFB1 G-20A (rs11362), DEFB1 C-44G (rs1800972) and DEFB1 G-52A (rs1799946) were genotyped either by Custom TaqMan® SNP Genotyping Assays…
