Prevalence of IGR2198a_1 and IGR2096a_1 genetic variants in Hungarian patients with Crohn's disease and ulcerative colitis
L Lakner, V Csöngei, L Magyari, L Járomi, E Sáfrány, C Sipeky, G Talián, Z Döbrönte, B Melegh · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: the development of Crohn's disease (CD) and ulcerative colitis (UC) is caused by both environmental factors and complex genetic predisposition. Genetic association was found between this two forms of inflammatory bowel disease (IBD) and IBD5 on chromosome 5q31 (Silverberg et al; Eur J Hum genet. 2007; 15:328). Aim of our study: to analyse the possible influence of two variants in this region IGR2096a_1 (rs12521868) and IGR2198a_1 (rs11739135) in Hungarian IBD patients. Patients and method: PCR/RFLP methods were used for detecting the various genotypes. We examined 226 patients with CD (105 males, 1…
