Alterations of MDR1 and MRP1 functional activity of colorectal malignancies in a prospective clinical trial
T Micsik, T Mersich, Z Baranyai, I Besznyák, A Zaránd, K Dede, P Nagy, B Atkári, F Jakab, A Lőrincz, G Kéri, I Peták, R Schwab · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: The ABC-transporters MDR1 and MRP1 are expressed in the normal mucosa of gastrointestinal tract. These proteins are extruding various drugs from cells and therefore can alter the sensitivity of colorectal cancer (CRC) cells – a phenomenon extensively studied previously by immune-histochemistry and real-time PCR techniques. However, posttranslational modifications influence the functional activity (MDR Activity Factor: MAF) of MDR proteins, so determination of functional activity can bring new insights into understanding the connection between resistance of colorectal cancer and ABC transporters. This…
