Histopathological evaluation of esophageal glandular metaplasias in the south Hungarian community

Since specialized intestinal metaplasia (SIM) is uniquely considered as a premalignant condition for esophageal adenocarcinoma, other esophageal metaplasias are commonly neglected. Therefore, the aim was to make standardized histopathological analysis focusing on the role of mucinous cardiac and Schaffer's glands, fundic, pancreatic acinar metaplasia (PAM) in the metaplastic process. Methods: Biopsy samples of 826 consecutive patients (mean age 55.6 ys, m/f 1.1/1) with endoscopic evidence of columnar lined esophagus were analyzed prospectively between 2004 and 2007. Dysplasia was confirmed by p53, K-ras and Ki67…