Secunder prevention with alpha-lipoic acid and vitamin E in porphyria cutanea tarda patients

Introduction: Decreased activity of uroporphyrinogen decarboxylase enzyme cause porphyria cutanea tarda (PCT). The activity of the cytochrome P450 lA2 appears to be another impotant etiological factor in PCT. Abnormal iron metabolism produced oxidative radicals by reactive intracellular iron. Vitamin E and alpha-lipoic acid are a potent antioxidant combination with the protective effects against lipid peroxidation, oxidative stress, inflammation, infection, and protein carbonyl formation. Aim: We investigated the effect of vitamin E and alpha-lipoic acid on porphyrin concentration, iron metabolism and redox home…