CareLit Fachartikel

Polymorphism within connective tissue growth factor (CTGF) gene strongly predicts the marker of the ß-cell mass in non diabetic subjects

O Pivovarova, E Fisher, MO Weickert, H Boeing, AFH Pfeiffer, N Rudovich · Diabetologie und Stoffwechsel · 2010 · Heft 04

Dokument
1108153
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
O Pivovarova, E Fisher, MO Weickert, H Boeing, AFH Pfeiffer, N Rudovich
Ausgabe
Heft 04 / 2010
Seiten
–
Erschienen: 2010-04-21 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0030-1253807

Zusammenfassung

Aims: Connective tissue growth factor (CTGF) is a key determinant of progressive pancreas fibrosis and is up-regulated in Type 2 diabetes mellitus (T2DM). Recent studies indicate that CTGF promotes fibrogenesis both by enhancing pancreatic stellate cells proliferation and by releasing proinflammatory cytokines. CTGF inactivation in mice compromises islet cell proliferation during embryogenesis. Methods: We investigated the effect of a common polymorphism rs9493150 located in the CTGF locus on diabetes risk in two independent German cohorts from the same geographical region. The association between CTGF polymorph…

Schlagworte

Association C-Peptide Connective Tissue Growth Factor Connective Tissue Diabetes Mellitus Cytokines Allele Berlin Diabetologie und Stoffwechsel