NKX2–3 RS10883365 is associated with disease susceptibility to both Crohn's disease and ulcerative colitis while IRGM RS13361189 variant allele increased the risk for Crohn's dise…
P Lakatos, N Meggyesi, L Kiss, M Koszarska, L Lakatos, T Molnar, I Altorjay, M Papp, Z Tulassay, P Miheller, J Papp, A Tordai, M Lukas, H Andrikovics · Zeitschrift für Gastroenterologie · 2010 · Heft 05
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Zusammenfassung
Background: Sequence variants in the autophagy gene IRGM and NKX2–3 has been reported to contribute to Crohn's disease (CD) Susceptibility while ECM1 to ulcerative colitis (UC) in genome-wide association scans in North America and Western Europe. The aim of this study was to investigate variants of the above genes and examine genotype-phenotype relationships in a independent Eastern European IBD cohorts. Methods: 1707 Hungarian and Czech subjects were analysed (CD: 810, age: 37.1±12.6 years, duration: 10.7±8.4 years and UC: 428, age: 43.7±15.0 years, duration: 12.6±9.9 years, and 469 healthy controls). IRGM rs13…
