Genetic polymorphisms of cytokine (IL28B, IL10R, LTA) genes in HCV infection
A Pár, P Kisfali, B Melegh, I Tornai, F Szalay, M Varga, M Papp, J Schuller, A Tusnádi, Z Nemes, Z Péterfi, B Hunyady, A Vincze, G Pár · Zeitschrift für Gastroenterologie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Since the host immune response against HCV depends on cytokines, which are under genetic control, we have studied polymorphisms in two pro-inflammatory (IL28B, lymphotoxin A=LTA) and in one anti-inflammatory cytokine (IL10)genes in HCV infection. The allel frequencies compared to healthy controls and the relationship between genetic polymorphisms and the response to PEG-IFN/ribavirin (P/R) treatment have been examined. Patients: 292 HCV genotype 1 patients have been studied, of them 172 treated with P/R. Sixty nine of 172 (40.11%) achieved sustained virological response (SVR). 104 healthy individuals…
