CareLit Fachartikel

Glucocorticoids potentiate IL-6 induced SP-B expression in H441 cells by enhancing the Jak/Stat signaling pathway

S Kunzmann, A Ladenburger, M Seehase, W Thomas, J Wirbelauer, BW Kramer, CP Speer · Klinische Pädiatrie · 2010 · Heft 06

Dokument
1108346
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
S Kunzmann, A Ladenburger, M Seehase, W Thomas, J Wirbelauer, BW Kramer, CP Speer
Ausgabe
Heft 06 / 2010
Seiten
–
Erschienen: 2010-06-09 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0030-1261407

Zusammenfassung

The respiratory distress syndrome (RDS) contributes to perinatal morbidity and mortality associated with preterm birth. Surfactant protein B (SP-B) is decreased in RDS. Both maternal antenatal steroid administration and chorioamnionitis reduce the incidence and severity of RDS. An important mediator in chorioamnionitis is interleukin-6 (IL-6) using the Jak-Stat signaling pathway for signaltransduction. We hypothesized that betamethasone (BTM) and dexamethasone (DEX) and IL-6 had synergistic effects on SP-B gene expression and Stat3 phosphorylation in H441 cells. DXM and BTM increased SP-B mRNA levels by 16.5 (13…

Schlagworte

Chorioamnionitis Betamethasone Dexamethasone Observation Cytokine After Klinische Pädiatrie