Dysfunction of plasmacytoid dendritic cells in preterm neonates – a cause of severe infections?
S Schueller, K Sadeghi, S Diesner, A Prusa, K Klebermasz, J Neumüller, H Helmer, PW Husslein, A Spittler, E Förster-Waldl · Klinische Pädiatrie · 2010 · Heft 06
Bibliografische Angaben
Zusammenfassung
Objective: Bacterial and viral infections are associated with high rates of morbidity and mortality in neonates, especially in preterm newborns. The mechanisms of altered immunological functions in neonates leading to severe courses of infections are yet a question of debate. Plasmacytoid dendritic cells (pDCs), although low in numbers in peripheral blood (PB), are strong producers of interferon alpha (IFN-a) after TLR9 stimulation. Patients and Methods: In order to analyze pDCs' impact on neonatal immune responses, we analyzed the frequency of pDCs in cord blood (CB) from term (n=20) and preterm neonates (n=20)…
