Anxiety is a risk factor for enhanced immune activation after bacterial antigen exposure in patients with functional gastrointestinal disorders
B Adam, T Liebregts, G Gerken, G Holtmann · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Infection and immune activation play a role in the pathogenesis of functional gastrointestinal disorders (FGID). Although clinical observations suggest that psychological disorders are important risk factors for the manifestation of post-infectious FGID very little is known about the role of psychological co-morbidity for cellular immune activation. We hypothesized that the immune response is modulated by psychological co-morbidities. We aimed (1) to characterize peripheral blood mononuclear cell (PBMC) mediated cytokine production and (2) the cellular immune response to bacterial antigen stimulation in FG…