NAFLD patients exhibit dysregulation of bile acid transport in association with apoptosis and liver fibrosis
P Kocabayoglu, LP Bechmann, J Schmitt, A Kahraman, JP Sowa, I Wedemeyer, J Treckmann, A Kilicarslan, M Odenthal, C Rust, G Gerken, A Geier, AE Canbay · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and may proceed to steatohepatitis with and without fibrosis. However, the underlying pathophysiological mechanisms involved in fibrogenesis in NAFLD are scarcely understood. Recent data suggest elevation of bile acids in NAFLD. We aimed to characterize bile acid transporter expression as well as corresponding apoptosis and fibrosis in a cohort of NAFLD patients. Methods: 49 morbidly obese patients who underwent bariatric surgery were included. Liver biopsies and serum samples were obtained during…
