CareLit Fachartikel

Association of common p53 and mdm2 variants with spontaneous and treatment induced viral clearance in patients with chronic hepatitis C infection

V Zimmer, F Grünhage, M Krawczyk, G Assmann, S Zeuzem, C Sarrazin, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08

Dokument
1108530
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
V Zimmer, F Grünhage, M Krawczyk, G Assmann, S Zeuzem, C Sarrazin, F Lammert
Ausgabe
Heft 08 / 2010
Seiten
–
Erschienen: 2010-08-03 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1263897

Zusammenfassung

Background & Aim: The tumor suppressor gene p53 has been implicated in the immune response to chronic hepatitis C virus (HCV) infection by modulation of interferon signalling (Dharel, Hepatology 2008). Common variants in p53 (SNP72 G/C) and its key negative regulator mdm2 (SNP309 T/G) affect p53′s apoptotic capacity and enhance mdm2 transcription, respectively (Whibley, Nat Rev Cancer 2009). We asked if these variants associate with spontaneous and therapeutic HCV clearance. Patients & methods: The two variants were genotyped in 176 chronic HCV infected patients undergoing standard treatment with peginterferon-α…

Schlagworte

Allele Hepatitis Treatment Failure Blood Donors Affect Blood Tumor Association Zeitschrift für Gastroenterologie