Anti-HDV-IgM testing in hepatitis delta revisited: Correlations with disease activity and response to pegylated interferon alfa-2a treatment
I Mederacke, C Yurdaydin, B Bremer, Y Çakaloğlu, A Erhardt, K Yalcin, K Zachou, S Gürel, B Heidrich, G Dalekos, HP Dienes, MP Manns, H Wedemeyer · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Delta hepatitis is the most severe form of chronic viral hepatitis. Diagnosis of HDV infection is usually based on anti-HDV-IgG and HDV RNA testing. However, detection and quantification of HDV RNA is not well standardized. Anti-HDV-IgM testing correlated with disease activity and treatment outcome in studies performed in the 80ies and 90ies. We re-examined the role of anti-HDV-IgM testing in samples obtained from the HIDIT-1 study, an international randomised multicenter trial investigating PegIFN-alfa-2a±adefovir vs. adefovir alone for the treatment of chronic delta hepatitis. Methods: 111 serum…
