Polymorphisms in inflammatory pathway genes and their associations with colorectal cancer risk

Introduction: Chronic inflammation is a well-established risk factor for colorectal cancer (CRC), and various inflammatory bowel diseases, such as chronic ulcerative colitis and Crohn's disease, predispose to CRC. Conclusive evidence for the significance of inflammation during neoplastic progression comes from studies of cancer risk among long-term users of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), which indicate that the regular NSAID use significantly reduces risk of CRC. The aim of this study was to test the hypothesis that polymorphisms in genes regulating inflammatory processes modula…