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Single nucleotide polymorphisms in Wnt signaling and apoptotic pathway genes and susceptibility to colorectal cancer

B Frank, M Hoffmeister, N Klopp, T Illig, J Chang-Claude, H Brenner · Das Gesundheitswesen · 2010 · Heft 09

Dokument
1108676
CareLit-ID
Jahr
2010
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Das Gesundheitswesen
Autor:innen
B Frank, M Hoffmeister, N Klopp, T Illig, J Chang-Claude, H Brenner
Ausgabe
Heft 09 / 2010
Seiten
–
Erschienen: 2010-09-02 00:00:00
ISSN
0941-3790
DOI
10.1055/s-0030-1266727

Zusammenfassung

Introduction: Constitutive activation of the canonical Wnt signaling pathway in consequence of mutations in APC, AXIN1 or CTNNB1 genes is regarded as initiating event in 90% of colorectal cancers (CRCs). Besides aberrant downstream target activation, numerous upstream Wnt signaling components were found deregulated in CRC. Additionally, Wnt signaling modulates apoptosis, encouraging CRC development and poor response to radiation. Therefore, we hypothesized that single nucleotide polymorphisms (SNPs) in Wnt signaling and apoptotic pathway genes affect CRC susceptibility. Material and Methods: This case-control st…

Schlagworte

Allele Association Apoptosis Population Affect Das Gesundheitswesen