CareLit Fachartikel
In the presence of ethanol TGF-β effects switch from pro-survival to apoptotic in hepatocytes
K Breitkopf-Heinlein, H Gaitantzi, Q Li, A Mueller, S Dooley · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1108783
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
Signalling of the pro-fibrogenic cytokine TGF-β is activated in liver disease including alcoholic liver disease (ALD). Since TGF-β was described as both, survival promoting or apoptosis inducing factor depending on the cellular context we analyzed its effects in combination with ethanol. The mild cytotoxic effects of ethanol or TGF-β on monolayer-cultured primary mouse hepatocytes is strongly enhanced when both substances were added simultaneously, resulting in strong apoptosis with cytochrome-C release from mitochondria and activation of Caspase 3. Ethanol (or the combination of ethanol and TGF-β) reduced basal…
Schlagworte
Apoptosis
Apoptosis Inducing Factor
Cytochrome C
Cytochrome
Caspase 3
Cytokine
After
Zeitschrift für Gastroenterologie
