CareLit Fachartikel
Molecular details on BMP-7 activity on TGF-beta1-mediated CTGF expression in myofibroblasts
M Esser, R Weiskirchen, SK Meurer · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1108784
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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Zusammenfassung
Background: In the setting of fibrogenic lesions, TGF-β1 drives cells to the myofibroblast phenotype and thereby causes excessive extracellular matrix (ECM) deposition. In the liver – as well as in other organs–BMP-7 has been described as an antifibrotic ligand abrogating profibrogenic TGF-β1 responses [1]. However, the exact molecular details of this antagonism have not been elucidated so far. To do so we employed a model system – L6E9 myoblasts – which transit into a myofibroblastic phenotype upon treatment with TGF-β1 [2]. In addition, we have already shown that in L6E9- myoblasts TGF-β1 responses are counter…
Schlagworte
BMP-7
L6E9
MAP-kinases
TGF-beta
myoblasts
myofibroblasts
Cycloheximide
Zeitschrift für Gastroenterologie
