IFN-gamma inhibits hepatic progenitor cell activation in chronic liver damage
H Weng, S Radaeva, Y Liu, Q Li, H Shen, R Muellenbach, T Huang, V Zimmer, F Lammert, J Chen, S Dooley · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: Hepatic progenitor cells (HPC) are thought to promote a periportal ductular reaction (DR) and contribute to periportal fibrosis in HCV- and non-alcholic steatohepatitis (NASH)-associated liver diseases. IFN-gamma is a well recognized fibrotic inhibitor in vitro and in vivo. The present study investigate the role of IFN-gamma in HPC activation in chronic HBV infected patients and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) treated mouse. Methods: Hepatic progenitor cells were quantified by Cytokeratin-19 (CK19) immunostaining in 110 HBV, as were oval cells (HPCs in rodents) in DDC treated w…
