MIF exerts anti-fibrotic effects in experimental liver fibrosis via CD74
D Heinrichs, M Jung, ML Berres, A Nellen, P Schmitz, R Bucala, C Trautwein, C Weber, J Bernhagen, HE Wasmuth · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Macrophage migration inhibitory factor (MIF) has been implicated in inflammatory diseases. Chronic inflammation is a mainstay of liver fibrosis but the specific role of MIF in liver scarring has not yet been elucidated. Here we uncover an unexpected anti-fibrotic role of MIF in vivo and in vitro. Methods: Liver fibrosis was induced by CCl4 and TAA in Mif‒/‒, Cd74‒/‒ mice and wild-type mice. Fibrosis was analyzed by histology (sirius red), hydroxyproline content and intrahepatic mRNA expression of fibrosis-related genes (Col1a1, Timp1, Tgfb1, Mmp2). In vitro, the effects of MIF on the proliferation and migr…
