Epigenetic and post-transcriptional mechanisms are responsible for disruption of the Hippo tumor suppressor pathway in human hepatocellular carcinoma
DF Calvisi, X Chen, C Ho, S Ladu, G Destefanis, S Mattu, S Delogu, SS Thorgeirsson, F Dombrowski, M Evert · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Mounting evidence indicates that disruption of the Hippo tumor suppressor pathway contributes to hepatocarcinogenesis. In this study, we investigated the expression levels of the members of the Hippo signaling in a collection of human hepatocellular carcinoma (HCC) as well as in in vivo and in vitro models. Thus, promoter and genomic status of Hippo pathway members were assessed in HCC by methylation and microsatellite analyses, while effects of Hippo modulation on HCC growth were evaluated in HCC cell lines. We found that suppression of FAT4, NF2, MST1, MST2, LATS1, LATS2 and SAV1 expression by promoter hyperme…
