CareLit Fachartikel

MLDP/ perilipin 5 is a widely expressed lipid droplet-associated protein with differential localization in striated myocytes and steatotic hepatocytes

M Hashani, LM Pawella, P Schirmacher, BK Straub · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1108792
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Hashani, LM Pawella, P Schirmacher, BK Straub
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269547

Zusammenfassung

Diseases associated with the accumulation of lipid droplets (LDs) are steadily increasing in western countries. LDs are near-ubiquitous, highly dynamic cell organelles, regulated by LD-associated proteins of the PAT-family (perilipin, adipophilin, TIP47; synonyms perilipin 1–3). Recently, in mouse models and derived cultured cells, MLDP (“myocardial lipid droplet-protein“, synonyms Ox-PAT, perilipin 5), another LD-associated protein of the PAT-family, has been described in highly oxidative tissues such as heart, red muscle and liver during fasting. Yet, little is known about MLDP expression in human tissues and…

Schlagworte

MLDP lipid droplet Adipocytes Antibodies Adipophilin Zeitschrift für Gastroenterologie