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Human hepatic organic anion transporter 7 is negatively regulated by hepatocyte growth factor

C Jüngst, J Eloranta, G Kullak-Ublick · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1108793
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Jüngst, J Eloranta, G Kullak-Ublick
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269557

Zusammenfassung

Organic anion transporters (OATs) are membrane proteins that are crucial for the uptake, distribution and elimination of exogenous and endogenous compounds. The human organic anion transporter 7 (hOAT7, SLC22A9) has recently been identified as the first liver-specific member of the OAT family, and an exchange of sulfate-conjugates and estrogens for butyrate by hOAT7 has been demonstrated. As the expression level is likely to affect transport activity, our aim is to study the transcriptional regulation of the hOAT7 gene. Hepatocyte growth factor (HGF) has a major impact upon liver cell physiology by acting via th…

Schlagworte

organic anion transporter transcriptional regulation hepatocyte growth factor Butyrate Affect Lead Actinomycin D Actinomycin Zeitschrift für Gastroenterologie