H2O2 rapidly activates the systemic iron hormone hepcidin independent of the IL-6/BMP6 network
G Millonig, I Ganzleben, G Casanovas, T Peccerella, HK Seitz, MU Muckenthaler, S Mueller · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: The liver-secreted peptide hepcidin is the key iron hormone at the systemic level. It decreases duodenal iron absorption and iron release by macrophages during conditions of excess iron by blocking the iron exporter ferroportin. In addition, IL-6 mediated upregulation of hepcidin during inflammation is the major mechanism of the so-called ‘anemia of chronic disease’. We here identify H2O2 which is co-released by inflammatory cells as potent transcriptional activator of hepcidin independent of upstream regulators IL-6 and BMP6. Material and Methods: H2O2 release (1–8µM) by immune cells was mimicked using pu…
