Hepatic differentiation of adipose-derived mesenchymal stem cells reduces recruitment of immune cells after transplantation into livers of CCl4 treated mice
S Ehnert, C Eipel, K Abshagen, A Othman, C Seeliger, U Stöckle, B Vollmar, J Henstler, AK Nussler · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Transplantation of hepatocytes is a therapeutic approach for diverse acute and chronic liver diseases. As the availability of primary cells is limited, there exists an increasing demand for hepatocyte-like cells that can be obtained by stem cell technology. Among which adipose-derived mesenchymal stem cells (Ad-MSCs) represent a promising source, as they are easily assessable and can be obtained in sufficient amounts. Human Ad-MSCs were isolated from different patients, with their informed consent according to ethical guidelines of the MRI. Hepatic differentiation was induced by addition of 5-azacytidine, FGF-4,…
